TyG指数与依洛尤单抗治疗急性冠脉综合征患者PCI术后不良事件的相关性

摘要/Abstract

摘要： 目的本研究旨在分析甘油三酯葡萄糖指数与PCI术后急性冠脉综合征患者,在PCSK9抑制剂干预后不良心血管事件发生率之间的相关性。方法选取2022年1月至2024年8月长春市中心医院心内科接受PCI治疗的280名急性冠脉综合征患者,经依洛尤单抗治疗为治疗组（106人）,他汀类药物治疗为对照组（174人）。通过二元Logistic回归,分析影响急性冠脉综合征患者不良心血管事件的危险因素,通过ROC曲线下面积,分析TyG指数对经依洛尤单抗治疗的急性冠脉综合征患者发生不良心血管事件的预测价值。结果依洛尤单抗治疗组与他汀类药物对照组在用药前 TyG 指数比较差异无统计学意义[8.94（8.66,9.29） vs 8.87（8.51,9.38）,P>0.05];用药后,依洛尤单抗治疗组 TyG 指数显著低于他汀类药物对照组[8.90（8.53,9.30） vs 8.78（8.40,9.14）],差异具有统计学意义（P<0.05）。二元 Logistic 回归分析结果表明,TyG 指数是经 PCI 术后接受依洛尤单抗治疗的急性冠脉综合征患者发生主要不良心血管事件的独立危险因素（P<0.05）。ROC 曲线分析显示,TyG 指数预测依洛尤单抗治疗患者 PCI 术后发生主要不良心血管事件的曲线下面积为 0.757（P<0.05）。结论 TyG指数对急性冠脉综合征经PCI术术后使用依洛尤单抗治疗患者发生MACE有预测价值。

关键词: TyG指数, 依洛尤单抗, 急性冠脉综合征, 经皮冠脉介入治疗, 心血管不良事件

孙雅楠, 赵东晖, 鲁硕. TyG指数与依洛尤单抗治疗急性冠脉综合征患者PCI术后不良事件的相关性[J]. 心血管病防治知识, 2026, 16(3): 12-15.

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