老年冠心病患者外周血NLR、PLR、SII变化与衰弱发展轨迹的相关性

摘要/Abstract

摘要： 目的分析老年冠心病患者外周血中性粒细胞/淋巴细胞比值（NLR）、血小板/淋巴细胞比值（PLR）、全身免疫炎症指数（SII）变化与衰弱发展轨迹的相关性。方法选取老年冠心病患者150例,老年冠心病合并衰弱患者150例纳入研究。比较两组临床资料及外周血NLR、PLR、SII水平,分析NLR、PLR、SII与衰弱（FRAIL）风险筛查评分的相关性。于入组时以及入组3、6、9、12个月、评估患者衰弱情况;采用潜类别增长模型识别老年冠心病患者衰弱轨迹的潜在类别;采用Logistic分析老年冠心病患者衰弱轨迹潜在类别的影响因素。结果衰弱组患者年龄、NT-proBNP、NLR、PLR、SII均高于非衰弱组（P<0.05）,LVEF低于非衰弱组（P<0.05）。NLR、PLR、SII与老年冠心病患者FRAIL评分均呈正相关（P<0.05）。识别出3种衰弱轨迹,其中低水平稳定组有51例,中水平上升组有43例,高水平上升组有56例。Logistic回归分析结果表明：相对低水平稳定组,年龄较大、LVEF较低,NT-proBNP、NLR、PLR、SII较高的患者更容易进入中水平上升组和高水平上升组（P<0.05）。结论老年冠心病患者衰弱存在三条不同的发展轨迹,年龄较大、LVEF、NT-proBNP、NLR、PLR、SII是其轨迹潜在类别的影响因素,需尽早针对可能的影响因素实施干预,以便控制衰弱的进展。

关键词: 冠心病, 中性粒细胞/淋巴细胞比值, 血小板/淋巴细胞比值, 系统免疫炎症指数, 衰弱

梁昕慧, 张成伟. 老年冠心病患者外周血NLR、PLR、SII变化与衰弱发展轨迹的相关性[J]. 心血管病防治知识, 2025, 15(19): 3-7.

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