微小RNA对血管平滑肌细胞的调控作用以及与支架内再狭窄的联系

摘要/Abstract

摘要： 血管平滑肌细胞（Vascular Smooth Muscle Cells,VSMCS）的增殖、迁移及凋亡与支架内再狭窄（In-Stent Restenosis, ISR）密切相关。微小RNA (microRNAs)在机体的新陈代谢和疾病发生发展等许多方面有着不可或缺的重要作用,对血管平滑肌细胞起着重要的调控作用,因此可能是防治支架内再狭窄的新热点。本文旨在阐述微小RAN对血管平滑肌细胞的调控作用以及与支架内再狭窄的联系。

曹小虎, 廖清池, 殷民明, 张真, 柳书可, 王健, 刘亚哲. 微小RNA对血管平滑肌细胞的调控作用以及与支架内再狭窄的联系[J]. 心血管病防治知识, 2020, 10(9): 93-96.

参考文献

[1] Zhang M, Zhou Y, Chen L, et al. An overview of potential molecular mechanisms involved in VSMC phenotypic modulation [J]. Histochem Cell Biol, 2016, No.2): 119-130.
[2] 姚雯, 赵金河. 冠心病介入治疗术后再狭窄防治的研究进展[J]. 中西医结合心脑血管病杂志, 2018, 16(23): 3456-3458.
[3] 李丹,颜渊鸳, 欧和生. 微小RNA在调控血管平滑肌细胞凋亡与心血管疾病的联系与临床应用[J]. 中国药学杂志, 2019, 54(08): 603-607.
[4] Simonson B, Das S. MicroRNA Therapeutics: the Next Magic Bullet[J]. Mini Rev Med Chem, 2015, No.6): 467-474.
[5] Tang Y, Xu Q, Peng H, et al. The role of vascular peroxidase 1 in ox-LDL-induced vascular smooth muscle cell calcification [J]. Atherosclerosis, 2015, No.2): 357-363.
[6] FM, J Y, Q M, et al. Expression status and clinical significance of lncRNA APPAT in the progression of atherosclerosis[J]. Peerj, 2018, e4246.
[7] KS M, M L, K S, et al. PTEN deficiency promotes pathological vascular remodeling of human coronary arteries[J]. JCI Insight, 2018,4.
[8] H H, CL W, LA W, et al. Nuclear PTEN functions as an essential regulator of SRF-dependent transcription to control smooth muscle differentiation[J]. Nat Commun, 2016, 10830.
[9] Yuan M, Wang X, Zhan Q, et al. Association of PTEN genetic polymorphisms with atherosclerotic cerebral infarction in the Han Chinese population[J]. J Clin Neurosci, 2012,12:1641-1645.
[10] Martini M, DeSantis M C, Braccini L, et al. PI3K/AKT signaling pathway and cancer: An updated review[J]. Ann Med, 2014,5-6.
[11] Zhai C, Cheng J, Mujahid H, et al. Selective Inhibition of PI3K/Akt/mTOR Signaling Pathway Regulates Autophagy of Macrophage and Vulnerability of Atherosclerotic Plaque[J]. PLoS One, 2014,3.
[12] Carnero A, Blanco-Aparicio C, Renner O, et al. The PTEN/PI3K/AKT Signalling Pathway in Cancer, Therapeutic Implications[J]. Curr Cancer Drug Targets, 2008,3:187-198.
[13] Xu C X, Xu L, Peng F Z, et al. MiR-647 promotes proliferation and migration of ox-LDL-treated vascular smooth muscle cells through regulating PTEN/PI3K/AKT pathway[J]. Eur Rev Med Pharmacol Sci, 2019, 23(16): 7110-7119.
[14] Nyberg S T, Fransson E I, Heikkil? K, et al. Job Strain and Cardiovascular Disease Risk Factors: Meta-Analysis of Individual-Participant Data from 47,000 Men and Women[J]. PLoS One, 2013, 2013.
[15] Zhang B, Zhang G, Wei T, et al. MicroRNA-25 protects smooth muscle cells against corticosterone-induced apoptosis(Article)[J]. Oxid Med Cell Longev, 2019
[16] Huang F, Li M, Fang Z, et al. Overexpression of MicroRNA-1 Improves the Efficacy of Mesenchymal Stem Cell Transplantation after Myocardial Infarction[J]. Cardiology, 2013,1: 18-30.
[17] Di Y, Zhang D, Hu T, et al. miR-23 regulate the pathogenesis of patients with coronary artery disease[J]. Int J Clin Exp Med, 2015,7: 11759-1169.
[18] Liu L, Cheng Z, Yang J. miR-23 regulates cell proliferation and apoptosis of vascular smooth muscle cells in coronary heart disease [J]. Pathol Res Pract, 2018, No.11): 1873-1878.
[19] Tian P, Yan L. Inhibition of MicroRNA-149-5p Induces Apoptosis of Acute Myeloid Leukemia Cell Line THP-1 by Targeting Fas Ligand (FASLG)[J]. Med Sci Monit, 2016, 5116-5123.
[20] Grieco F A, Sebastiani G, Juan-Mateu J, et al. MicroRNAs miR-23a-3p, miR-23b-3p, and miR-149-5p Regulate the Expression of Proapoptotic BH3-Only Proteins DP5 and PUMA in Human Pancreatic β-Cells[J]. Diabetes (DIABETES), 2017,1: 100-112.
[21] Jin L, 2,3, Li Y, 2,3, Liu J, 3,4, et al. Tumor suppressor miR-149-5p is associated with cellular migration, proliferation and apoptosis in renal cell carcinoma[J]. Mol Med Report, 2016,6: 5386-5392.
[22] Li C, Ni J, Liu Y-X, et al. Response of MiRNA-22-3p and MiRNA-149-5p to Folate Deficiency and the Differential Regulation of MTHFR Expression in Normal and Cancerous Human Hepatocytes[J]. PLoS One, 2017, 2017.
[23] Zhang B, Dong Y, Liu M, et al. miR-149-5p Inhibits Vascular Smooth Muscle Cells Proliferation, Invasion, and Migration by Targeting Histone Deacetylase 4 (HDAC4)[J]. Med Sci Monit, 2019, 7581-7590.
[24] Guida N, Laudati G, Mascolo L, et al. p38/Sp1/Sp4/HDAC4/BDNF Axis Is a Novel Molecular Pathway of the Neurotoxic Effect of the Methylmercury [J]. Front Neurosci, 2017
[25] Yang Z, Liu Y, Qin L, et al. Cathepsin H-Mediated Degradation of HDAC4 for Matrix Metalloproteinase Expression in Hepatic Stellate Cells: Implications of Epigenetic Suppression of Matrix Metalloproteinases in Fibrosis through Stabilization of Class IIa Histone Deacetylases[J]. Am J Pathol, 2017,4:781-97.
[26] Liu Q, Zhang X, Yin C, et al. HDAC4 is expressed on multiple T cell lineages but dispensable for their development and function[J]. Oncotarget, 2017,11: 17562-17572.
[27] Hu W, Chang G, Zhang M, et al. MicroRNA-125a-3p affects smooth muscle cell function in vascular stenosis[J]. J Mol Cell Cardiol, 2019, 85-94.
[28] Sun Y, Liu W-Z, Liu T, et al. Signaling pathway of MAPK/ERK in cell proliferation, differentiation, migration, senescence and apoptosis[J]. J Recept Signal Transduct Res, 2015,6: 600-604.
[29] Deschênes-Simard X, Kottakis F, Meloche S, et al. ERKs in Cancer: Friends or Foes?[J]. Cancer Res, 2014,2: 412-419.
[30] Leeper* N J, Raiesdana A, Kojima Y, et al. MicroRNA-26a is a novel regulator of vascular smooth muscle cell function[J]. J Cell Physiol, 2011,4: 1035-1043.
[31] B I, P D, MW F. An emerging role for the miR-26 family in cardiovascular disease[J]. Trends Cardiovasc Med, 2014,6: 241-248.
[32] Watterston C, Zeng L, Onabadejo A, et al. MicroRNA26 attenuates vascular smooth muscle maturation via endothelial bmp signalling(Article)[J]. PLoS Genetics, 2019,5.