麝香保心丸对冠状动脉非阻塞性心肌梗死患者炎性因子及心功能的影响分析

摘要/Abstract

摘要： 目的探讨麝香保心丸对冠状动脉非阻塞性心肌梗死(MINOCA)患者炎性介质及短期心功能的影响。方法收集冠状动脉非阻塞性心肌梗死患者45例,随机分为对照组和观察组,对照组采用常规冠心病二级预防治疗,观察组在常规治疗基础上加用麝香保心丸。采集并检测患者入院24h内血清肌酸激酶同工酶(CK-MB)、心肌肌钙蛋白I(cTnI)、氨基末端前体脑钠肽原(NT-proBNP)水平及超敏C反应蛋白(hs-CRP)、白细胞介素-6(IL-6)及肿瘤坏死因子-α(TNF-α)水平,检测两组患者入院24h内及治疗1月时经胸多普勒超声心动图检查的左心室收缩末期内径(LVSDD)、左心室舒张末期内径(LVEDD)、左心室射血分数(LVEF)及6min步行距离(6WMD),分析比较两组间差异。结果与对照组比较,观察组患者治疗1个月CK-MB、cTnI及NT-proBNP水平均更低(均P<0.05),炎性因子hs-CRP、IL-6及TNF-α水平下降更显著(均P<0.05),LVEDD更短(P<0.05)、LVEF更高(P<0.05)及6WMD更长(P<0.05),组间比较均具有显著统计学差异。结论麝香保心丸有助于减轻MINOCA患者的炎症反应及心肌损伤,改善患者的心功能及提高生活质量。

关键词: 麝香保心丸, 冠状动脉非阻塞性心肌梗死, 炎症, 心功能

吴斌, 胡海峰, 张思思, 苏斌杰, 项美玲, 谢达奇. 麝香保心丸对冠状动脉非阻塞性心肌梗死患者炎性因子及心功能的影响分析[J]. 心血管病防治知识, 2020, 10(29): 32-35.

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