65岁以上老年人颈动脉斑块与血流变的关系研究

摘要/Abstract

摘要： 目的研究社区门诊65岁以上老年人颈动脉斑块形成与血流变异常的关系。方法选择社门诊区登记的65岁以上老年人共120例,其中健康者45例（对照组）,心脑血管疾病患者75例（观察组）;采用多普勒超声检测颈动脉斑块,自动血流变测试仪检测血流变指标,包括全血粘度、血浆粘度、红细胞压积（HCT）、血沉（ESR）、血浆纤维蛋白原（Fib）。结果观察组颈动脉斑块形成率和数量明显高于对照组,差异有统计学意义（P<0.05）。观察组全血粘度、血浆粘度、HCT、Fib水平均明显高于对照组,ESR降低,差异有统计学意义（P<0.05）。结论 65岁以上老年人心脑血管疾病的发生与颈动脉斑块形成与血流变异常有关。

关键词: 颈动脉斑块, 血流变, 心脑血管疾病

Abstract: Objective To investigate the association between carotid plaque formation and abnormal hemorheology in the elderly above 65 years of age in the community outpatient service. Methods A total of 120 elderly residents who were registered in the community outpatient service were enrolled, among whom there were 45 healthy residents (control group) and 75 patients with cerebrovascular and cardiovascular diseases (observation group). Color Doppler ultrasound was used to detect carotid plaque, and an automatic hemorheologicalanalyzer was used to measure hemorheologicalindices, including whole blood viscosity, plasma viscosity, hematocrit (HCT), erythrocyte sedimentation rate (ESR), and plasma fibrinogen (Fib). Results The observation group had significantly higher rate of carotid plaque formation and number of carotid plaques than the control group (P <0.05). Compared with the control group, the observation group had significantly higher whole blood viscosity, plasma viscosity, HCT, and Fib level and a significantly lower ESR (P<0.05). ConclusionThe development of cerebrovascular and cardiovascular diseases and carotid plaque formation are associated with abnormal hemorheologyin the elderly above 65 years of age.

Key words: Carotid plaque, Hemorheology, Cerebrovascular and cardiovascular diseases

甘灵玲. 65岁以上老年人颈动脉斑块与血流变的关系研究[J]. 心血管病防治知识, 2019, 9(17): 41-43.

GAN Ling-ling. Association between carotid plaque and hemorheology in the elderly above 65 years of age[J]. Prevention and Treatment of Cardiovascular Disease, 2019, 9(17): 41-43.

参考文献

[1] 张艳春,秦江梅,杨晓倩,等.北京市社区慢病患者心脑血管疾病风险预测研究[J].中国全科医学,2017,05(20):590-594.
[2] 孙宏慧,周和,黎丽芸.社区老年心脑血管疾病患者自我管理现状及影响因素分析[J].实用医学杂志,2013,29(13):2212-2214.
[3] 王一,潘鸣镝,吴建华,等.2001-2010年上海市卢湾区居民心脑血管疾病死亡动态分析[J].中华疾病控制杂志,2012,16(3):191-194.
[4] 王鹏,修春红,王岚峰.颈动脉粥样硬化与心脑血管疾病的关系[J].中国动脉硬化杂志,2014,22(11):1175-1178.
[5] 孟竹,梅少平,李梅,等.急性冠脉综合征患者颈动脉斑块特征及其与循环标记物的相关性[J].中国循证心血管医学杂志,2017,3(9):280-282,289.
[6] 孔维敏,刘林,薛存屹,等.颈动脉内中膜增厚及斑块对中风和冠心病事件的影响[J].中国热带医学,2016,1(16):76-79.
[7] 勇强,张蕾,田菊,等.颈动脉斑块检查标准化流程[J].血管与腔内血管外科杂志,2016,4(2):269-273,268.
[8] 王鹏,修春红,王岚峰.颈动脉粥样硬化与心脑血管疾病的关系[J].中国动脉硬化杂志,2014,22(11):1175-1178.
[9] 李雯,周勇,刘雪梅,等.中老年人群颈动脉斑块的检出率及其影响因素[J].中华高血压杂志,2012,20(3):232-236.
[10] 肖天祎,刘焱,李继来,等.颈动脉粥样硬化评分与缺血性卒中的诊断[J].北京大学学报(医学版),2016,6(48):1000-1005.
[11] 栗静,石正洪.颈动脉易损性斑块的研究进展[J].中风与神经疾病杂志,2017,1(34):88-91.
[12] 陈善,周晓秋,叶梁,等.辛伐他汀对轻中度高血压合并高血脂症患者血清炎症介质、血小板活化功能和血液流变学的影响[J].中华高血压杂志,2015,12(5):477-481.
[13] 秦任甲. 血液流变学临床应用30多年的国内进展[J].微循环学杂志,2014,2(24):5-8.
[14] 于明,贾海玉,李国春.急性脑出血患者血液流变学指标变化的相关研究[J].临床神经病学杂志,2017,1(30):1-4.
[15] 商施锞,张玉笛,李荣亨.血液流变学与临床[J].现代医学,2017,1(45):163-167.
[16] 郭华,陈炅,索冬卫.瑞舒伐他汀对冠心病患者心功能、血脂水平、血液流变学水平及内皮功能的影响[J].中国生化药物杂志,2015,6(2):98-100,104.
[17] 贾东佩. 降纤酶对脑梗塞急性期患者APTT、PT与血液流变学的影响[J].中国生化药物杂志,2014,10(7):124-125,128.