Prevention and Treatment of Cardiovascular Disease ›› 2025, Vol. 15 ›› Issue (24): 136-140.
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Online:2025-12-25
Published:2026-04-07
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| [1] | Vaduganathan M,Mensah GA,Turco JV,et al.The Global Burden of Cardiovascular Diseases and Risk:A Compass for Future Health[J].J Am Coll Cardiol,2022,80(25):2361-2371. |
| [2] | Huang H,Huang B,Li Y,et al.Uric acid and risk of heart failure:a systematic review and meta-analysis[J].Eur J Heart Fail,2014,16(1):15-24. |
| [3] | Kanellis J,Watanabe S,Li JH,et al.Uric acid stimulates monocyte chemoattractant protein-1 production in vascular smooth muscle cells via mitogen-activated protein kinase and cyclooxygenase-2[J].Hypertension,2003,41(6):1287-1293. |
| [4] | Corry DB,Eslami P,Yamamoto K,et al.Uric acid stimulates vascular smooth muscle cell proliferation and oxidative stress via the vascular renin-angiotensin system[J].Journal of Hypertension,2008,26(2):269-275. |
| [5] | Johnson RJ,Kang DH,Feig D,et al.Is there a pathogenetic role for uric acid in hypertension and cardiovascular and renal disease[J].Hypertension,2003,41(6):1183-1190. |
| [6] | 刘淑党,林静娜,邱慧娜,等.2型糖尿病患者血尿酸水平与发生动脉粥样硬化性心血管疾病事件风险的影响研究[J].中国糖尿病杂志,2022,30(4):241-245. |
| [7] | 顾淑君,张秋伊,周正元.2型糖尿病人群中高尿酸血症与心血管病死亡风险的队列研究[J].实用预防医学,2021,28(4):435-438. |
| [8] | Gaubert M,Bardin T,Cohen-Solal A,,et al.Hyperuricemia and Hypertension,Coronary Artery Disease,Kidney Disease:From Concept to Practice[J].International Journal of Molecular Sciences,2020,21(11):4066. |
| [9] | Braga TT,Forni MF,Correa-Costa M,et al.Soluble Uric Acid Activates the NLRP3 Inflammasome[J].Scientific Reports,2017,7(1):39884. |
| [10] | WANG M,LIN X,YANG X,et al.Research progress on related mechanisms of uric acid activating NLRP3 inflammasome in chronic kidney disease[J].Renal Failure,2022,44(1):615-624. |
| [11] | ZHANG H,MA Y,CAO R,et al.Soluble uric acid induces myocardial damage through activating the NLRP3 inflammasome[J].Journal of Cellular and Molecular Medicine,2020,24(15):8849-8861. |
| [12] | LI H,QIAN F,LIU H,et al.Elevated Uric Acid Levels Promote Vascular Smooth Muscle Cells (VSMC) Proliferation via an Nod-Like Receptor Protein 3 (NLRP3)-Inflammasome-Dependent Mechanism[J].Medical Science Monitor,2019,25:8457-8464. |
| [13] | LI H,QIAN F,LIU H,et al.Elevated Uric Acid Levels Promote Vascular Smooth Muscle Cells (VSMC) Proliferation via an Nod-Like Receptor Protein 3 (NLRP3)-Inflammasome-Dependent Mechanism[J].Medical Science Monitor,2019,25:8457-8464. |
| [14] | JIANG C,XIE S,YANG G,et al.Spotlight on NLRP3 Inflammasome:Role in Pathogenesis and Therapies of Atherosclerosis[J].Journal of Inflammation Research,2021,14:7143-7172. |
| [15] | HONG P,GU R N,LI F X,et al.NLRP3 inflammasome as a potential treatment in ischemic stroke concomitant with diabetes[J].Journal of Neuroinflammation,2019,16(1):121. |
| [16] | ZHANG C,YANG Y.Targeting toll-like receptor 4 (TLR4) and the NLRP3 inflammasome:Novel and emerging therapeutic targets for hyperuricaemia nephropathy[J].Biomolecules and Biomedicine,2024,24(4):688-697. |
| [17] | FRANCHI L,EIGENBROD T,MUÑOZ-PLANILLO R,et al.The inflammasome:a caspase-1-activation platform that regulates immune responses and disease pathogenesis[J].Nature Immunology,2009,10(3):241-247. |
| [18] | WOLFF C H J.Innate Immunity and the Pathogenicity of Inhaled Microbial Particles[J].International Journal of Biological Sciences,2011,7(3):261-268. |
| [19] | JOOSTEN L A B,CRIŞAN T O,BJORNSTAD P,et al.Asymptomatic hyperuricaemia:a silent activator of the innate immune system[J].Nature Reviews Rheumatology,2020,16(2):75-86. |
| [20] | ZHAO S,LI X,WANG J,et al.The Role of the Effects of Autophagy on NLRP3 Inflammasome in Inflammatory Nervous System Diseases[J].Frontiers in Cell and Developmental Biology,2021,9:616625. |
| [21] | KRAFT V A N,BEZJIAN C T,PFEIFFER S,et al.GTP Cyclohydrolase 1/Tetrahydrobiopterin Counteract Ferroptosis through Lipid Remodeling[J].ACS Central Science,2020,6(1):41-53. |
| [22] | ABAIS J M,XIA M,ZHANG Y,et al.Redox Regulation of NLRP3 Inflammasomes:ROS as Trigger or Effector?[J].Antioxidants & Redox Signaling,2015,22(13):1111-1129. |
| [23] | ELLIOTT E I,SUTTERWALA F S.Initiation and perpetuation of NLRP3 inflammasome activation and assembly[J].Immunological Reviews,2015,265(1):35-52. |
| [24] | JIN C,FLAVELL R A.Molecular Mechanism of NLRP3 Inflammasome Activation[J].Journal of Clinical Immunology,2010,30(5):628-631. |
| [25] | SAITOH T,AKIRA S.Regulation of inflammasomes by autophagy[J].Journal of Allergy and Clinical Immunology,2016,138(1):28-36. |
| [26] | MIZUSHIMA N,LEVINE B,CUERVO A M,et al.Autophagy fights disease through cellular self-digestion[J].Nature,2008,451(7182):1069-1075. |
| [27] | FUSCO R,SIRACUSA R,GENOVESE T,et al.Focus on the Role of NLRP3 Inflammasome in Diseases[J].International Journal of Molecular Sciences,2020,21(12):4223. |
| [28] | MCKEE C M,COLL R C.NLRP3 inflammasome priming:A riddle wrapped in a mystery inside an enigma[J].Journal of Leukocyte Biology,2020,108(3):937-952. |
| [29] | ZHOU Y,FANG L,JIANG L,et al.Uric Acid Induces Renal Inflammation via Activating Tubular NF-κB Signaling Pathway[J].PLOS ONE,2012,7(6):e39738. |
| [30] | LI Y,ZHAO Z,LUO J,et al.Apigenin ameliorates hyperuricemic nephropathy by inhibiting URAT1 and GLUT9 and relieving renal fibrosis via the Wnt/β-catenin pathway[J].Phytomedicine,2021,87:153585. |
| [31] | TAN R J,ZHOU D,ZHOU L,et al.Wnt/β-catenin signaling and kidney fibrosis[J].Kidney International Supplements,2014,4(1):84-90. |
| [32] | HAO S,HE W,LI Y,et al.Targeted Inhibition of β-Catenin/CBP Signaling Ameliorates Renal Interstitial Fibrosis[J].Journal of the American Society of Nephrology,2011,22(9):1642-1653. |
| [33] | LI S S,SUN Q,HUA M R,et al.Targeting the Wnt/β-Catenin Signaling Pathway as a Potential Therapeutic Strategy in Renal Tubulointerstitial Fibrosis[J].Frontiers in Pharmacology,2021,12:719880. |
| [34] | HE W,DAI C,LI Y,et al.Wnt/β-Catenin Signaling Promotes Renal Interstitial Fibrosis[J].Journal of the American Society of Nephrology,2009,20(4):765-776. |
| [35] | STERN S,HILTON B J,BURNSIDE E R,et al.RhoA drives actin compaction to restrict axon regeneration and astrocyte reactivity after CNS injury[J].Neuron,2021,109(21):3436-3455.e9. |
| [36] | 孙广东.Rho/Rock通路在大鼠肾间质纤维化发生机制中的作用及阿魏酸钠改善效果的研究[D].长春:吉林大学,2007. |
| [37] | CAO Y,WANG Y,LI W,et al.Fasudil attenuates oxidative stress-induced partial epithelial-mesenchymal transition of tubular epithelial cells in hyperuricemic nephropathy via activating Nrf2[J].European Journal of Pharmacology,2024,975:176640. |
| [38] | MING X F,VISWAMBHARAN H,BARANDIER C,et al.Rho GTPase/Rho Kinase Negatively Regulates Endothelial Nitric Oxide Synthase Phosphorylation through the Inhibition of Protein Kinase B/Akt in Human Endothelial Cells[J].Molecular and Cellular Biology,2002,22(24):8467-8477. |
| [39] | CABRAL-PACHECO G A,GARZA-VELOZ I,CASTRUITA-DE LA ROSA C,et al.The Roles of Matrix Metalloproteinases and Their Inhibitors in Human Diseases[J].International Journal of Molecular Sciences,2020,21(24):9739. |
| [40] | SPECA S,GIUSTI I,RIEDER F,et al.Cellular and molecular mechanisms of intestinal fibrosis[J].World Journal of Gastroenterology,2012,18(28):3635-3661. |
| [41] | SHIRVAIKAR N,MARQUEZ-CURTIS L A,JANOWSKA-WIECZOREK A.Hematopoietic Stem Cell Mobilization and Homing after Transplantation:The Role of MMP-2,MMP-9,and MT1-MMP[J].Biochemistry Research International,2012,2012:685267. |
| [42] | SUN Y,LIU W Z,LIU T,et al.Signaling pathway of MAPK/ERK in cell proliferation,differentiation,migration,senescence and apoptosis[J].Journal of Receptors and Signal Transduction,2015,35(6):600-604. |
| [43] | WANG J C,TSAI S H,TSAI H Y,et al.Hyperuricemia exacerbates abdominal aortic aneurysm formation through the URAT1/ERK/MMP-9 signaling pathway[J].BMC Cardiovascular Disorders,2023,23(1):55. |
| [44] | CHEN Y,WAQAR A B,NISHIJIMA K,et al.Macrophage-derived MMP-9 enhances the progression of atherosclerotic lesions and vascular calcification in transgenic rabbits[J].Journal of Cellular and Molecular Medicine,2020,24(7):4261-4274. |
| [45] | PRADO A F,PERNOMIAN L,AZEVEDO A,et al.Matrix metalloproteinase-2-induced epidermal growth factor receptor transactivation impairs redox balance in vascular smooth muscle cells and facilitates vascular contraction[J].Redox Biology,2018,18:181-190. |
| [46] | NEWBY A C.Matrix metalloproteinases regulate migration,proliferation,and death of vascular smooth muscle cells by degrading matrix and non-matrix substrates[J].Cardiovascular Research,2006,69(3):614-624. |
| [47] | SHARMIN N,NGANWUCHU C C,NASIM M T.Targeting the TGF-β signaling pathway for resolution of pulmonary arterial hypertension[J].Trends in Pharmacological Sciences,2021,42(7):510-513. |
| [48] | WANG N,REN G D,ZHOU Z,et al.Cooperation of myocardin and smad2 in inducing differentiation of mesenchymal stem cells into smooth muscle cells[J].IUBMB Life,2012,64(4):331-339. |
| [49] | LONG X,MIANO J M.Transforming Growth Factor-β1 (TGF-β1) Utilizes Distinct Pathways for the Transcriptional Activation of MicroRNA 143/145 in Human Coronary Artery Smooth Muscle Cells[J].Journal of Biological Chemistry,2011,286(34):30119-30129. |
| [50] | LASSÈGUE B,SOrescu D,SZÖCS K,et al.Novel gp91phox Homologues in Vascular Smooth Muscle Cells[J].Circulation Research,2001,88(9):888-894. |
| [51] | OTANI N,OUCHI M,MIZUTA E,et al.Dysuricemia—A New Concept Encompassing Hyperuricemia and Hypouricemia[J].Biomedicines,2023,11(5):1255. |
| [52] | SAUTIN Y Y,NAKAGAWA T,ZHARIKOV S,et al.Adverse effects of the classic antioxidant uric acid in adipocytes:NADPH oxidase-mediated oxidative/nitrosative stress[J].American Journal of Physiology-Cell Physiology,2007,293(2):C584-C596. |
| [53] | YU M A,SÁNCHEZ-LOZADA L G,JOHNSON R J,et al.Oxidative stress with an activation of the renin-angiotensin system in human vascular endothelial cells as a novel mechanism of uric acid-induced endothelial dysfunction[J].Journal of Hypertension,2010,28(6):1234-1242. |
| [54] | LUO C,LIAN X,HONG L,et al.High Uric Acid Activates the ROS-AMPK Pathway,Impairs CD68 Expression and Inhibits OxLDL-Induced Foam-Cell Formation in a Human Monocytic Cell Line,THP-1[J].Cellular Physiology and Biochemistry,2016,40(3-4):538-548. |
| [55] | AUCLAIR G,GUIBERT S,BENDER A,et al.Ontogeny of CpG island methylation and specificity of DNMT3 methyltransferases during embryonic development in the mouse[J].Genome Biology,2014,15(12):545. |
| [56] | TANG L,XU Y,WEI Y,et al.Uric acid induces the expression of TNF-α via the ROS-MAPK-NF-κB signaling pathway in rat vascular smooth muscle cells[J].Molecular Medicine Reports,2017,16(5):6928-6933. |
| [57] | RUSSO E,BERTOLOTTO M,ZANETTI V,et al.Role of Uric Acid in Vascular Remodeling:Cytoskeleton Changes and Migration in VSMCs[J].International Journal of Molecular Sciences,2023,24(3):2960. |
| [58] | 马瑞刚,张勇,孙婷婷,等.多梳抑制复合体PRC1的核心组分CBX家族蛋白在表观遗传调控中的作用[J].浙江大学学报(英文版)B辑(生物医学与生物技术),2014,15(5):412-428. |
| [59] | LU Y,ZHANG H,HAN M,et al.Impairment of Autophagy Mediates the Uric-Acid-Induced Phenotypic Transformation of Vascular Smooth Muscle Cells[J].Pharmacology,2023,109(1):34-42. |
| [60] | SHINDE A V,FRANGOGIANNIS N G.Fibroblasts in myocardial infarction:A role in inflammation and repair[J].Journal of Molecular and Cellular Cardiology,2014,70:74-82. |
| [61] | 王妍琦.尿酸通过microRNA-155促进心脏成纤维细胞胶原合成及炎性分泌[D].青岛:青岛大学,2020. |
| [62] | CHENG X W,CHEN Z F,WAN Y F,et al.Long Non-coding RNA H19 Suppression Protects the Endothelium Against Hyperglycemic-Induced Inflammation via Inhibiting Expression of miR-29b Target Gene Vascular Endothelial Growth Factor a Through Activation of the Protein Kinase B/Endothelial Nitric Oxide Synthase Pathway[J].Frontiers in Cell and Developmental Biology,2019,7:312. |
| [63] | 孙锁柱,程波,吴西钊,等.大鼠尿酸性肾病肾小管上皮细胞凋亡、增殖、表型转化及转化生长因子β1表达关系[J].北京师范大学学报(自然科学版),2008(3):271-275. |
| [64] | WANG G,KWAN B C H,LAI F M M,et al.Urinary miR-21,miR-29,and miR-93:Novel Biomarkers of Fibrosis[J].American Journal of Nephrology,2012,36(5):412-418. |
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