Abstract: Objective To investigate the influenceof hyperuricemia on the severity of coronary stenosis anddisease conditions of patients with acute myocardial infarction (AMI)and their prognosis after percutaneous coronary intervention (PCI). Methods A retrospective analysis was performed for thedata of 298 patients who underwent coronary angiography in Department of Cardiovascular Medicine inour hospital from May 2021 to October 2022, and they were divided into three groups according to related examination results. Clinical data were compared betweenthe three groups, and the correlationbetween the level of serum uric acid(SUA)and the degree of coronary artery disease was analyzed. The AMI group was divided into two subgroups based on the diagnosis of hyperuricemia, and the influence of hyperuricemia on the degree of coronary stenosis, diseaseseverity, and prognosis wasanalyzed. Alogistic regression analysis was used to investigatethe risk factors formajor adverse cardiacevents (MACE) in and out of hospital inAMI patients. Results The patients withAMIhad a significantly higher level of SUA than those with unstable angina pectoris (UA) or stable angina pectoris (SAP)(P<0.05). SUA level was positively correlated with Gensini score for coronary stenosis in all patients(r = 0.171, P<0.05), and the patients withAMI had a significantly higher Gensini score than the other two groups (P<0.05). TheAMI patients diagnosed with hyperuricemia had significantly higher Gensini score, Grace score, and proportion of high-risk patients than those without hyperuricemia (P<0.05), with a significantly higher possibility of MACE in and out of hospital (P<0.05). The logistic regression analysis showed that hyperuricemia was an independent risk factor for MACE in and out of hospital in patients with AMI (P<0.05). Conclusion Hyperuricemia can increasethe severity of coronary stenosis and disease conditions and lead to a poorer prognosis of AMI patients.

Key words: Hyperuricemia, Acute myocardial infarction