全身免疫炎症指数与急性心肌梗死相关性的研究进展

摘要/Abstract

摘要： 急性心肌梗死是导致全球人民致死致残的主要原因之一。炎症反应与急性心肌梗死的发生和发展密切相关,炎症相关的生物标志物在急性心肌梗死的基础与临床研究中均受到广泛关注。近年来,越来越多的研究表明,全身免疫炎症指数是一种新型炎症生物标志物,已被用来研究与急性心肌梗死的相关性。本文旨在探讨全身免疫炎症指数与急性心肌梗死发生发展的关系,以及该指数作为急性心肌梗死风险预测因子的研究概况等进行综述。

李琴, 赵明才, 陈姝. 全身免疫炎症指数与急性心肌梗死相关性的研究进展[J]. 心血管病防治知识, 2025, 15(11): 141-144.

参考文献

[1] Thygesen K, Alpert JS, Jaffe AS, et al.Fourth Universal Definition of Myocardial Infarction (2018)[J]. J Am Coll Cardiol, 2018, 72(18):2231-2264.
[2] Damluji AA, van Diepen S, Katz JN, et al. Mechanical Complications of Acute Myocardial Infarction: A Scientific Statement From the American Heart Association[J]. Circulation, 2021, 144(2):e16-e35.
[3] Li Q, Ma X, Shao Q, et al.Prognostic Impact of Multiple Lymphocyte-Based Inflammatory Indices in Acute Coronary Syndrome Patients[J]. Front Cardiovasc Med, 2022, 9:811790.
[4] Jin Z, Wu Q, Chen S, et al.The Associations of Two Novel Inflammation Indexes, SII and SIRI with the Risks for Cardiovascular Diseases and All-Cause Mortality: A Ten-Year Follow-Up Study in 85,154 Individuals[J]. J Inflamm Res, 2021, 14:131-140
[5] Xia Y, Xia C, Wu L, et al.Systemic Immune Inflammation Index (SII), System Inflammation Response Index (SIRI) and Risk of All-Cause Mortality and Cardiovascular Mortality: A 20-Year Follow-Up Cohort Study of 42,875 US Adults[J], J Clin Med, 2023, 12(3):1128.
[6] Hu B, Yang XR, Xu Y, et al.Systemic immune-inflammation index predicts prognosis of patients after curative resection for hepatocellular carcinoma[J]. Clin Cancer Res, 2014, 20(23):6212-22.
[7] Damluji AA, van Diepen S, Katz JN, et al. Mechanical Complications of Acute Myocardial Infarction: A Scientific Statement From the American Heart Association[J]. Circulation, 2021, 144(2):e16-e35.
[8] Falk E.Pathogenesis of atherosclerosis[J]. J Am Coll Cardiol, 2006, 47(8 Suppl):C7-12.
[9] Hansson GK.Inflammation, atherosclerosis, and coronary artery disease[J]. N Engl J Med, 2005, 352(16):1685-95.
[10] Balta S, Ozturk C.The platelet-lymphocyte ratio: A simple, inexpensive and rapid prognostic marker for cardiovascular events[J]. Platelets, 2015, 26(7):680-1.
[11] Xie F, Yu Z, Xiong Y, et al.Systemic immune-inflammation index and in-stent restenosis in patients with acute coronary syndrome: a single-center retrospective study[J]. Eur J Med Res, 2024, 29(1):145.
[12] Han K, Shi D, Yang L, et al.Prognostic value of systemic inflammatory response index in patients with acute coronary syndrome undergoing percutaneous coronary intervention[J]. Ann Med, 2022, 54(1):1667-1677.
[13] Pinelli A, Trivulzio S, Rossoni G, et al.Factors involved in sudden coagulation observed in patients with acute myocardial infarction[J]. In Vivo, 2012, 26(6):1021-5.
[14] Jain K, Tyagi T, Gu SX, et al.Demographic diversity in platelet function and response to antiplatelet therapy[J]. Trends Pharmacol Sci, 2025, 46(1):78-93.
[15] Sheng J, Yang S, Gu N, et al.Systemic immune inflammation index is associated with in-stent neoatherosclerosis and plaque vulnerability: An optical coherence tomography study[J]. Heliyon, 2024, 10(16):e36486.
[16] Wei X, Zhang Z, Wei J, et al.Association of systemic immune inflammation index and system inflammation response index with clinical risk of acute myocardial infarction[J]. Front Cardiovasc Med, 2023 , 10:1248655.
[17] Fang X, Ji Y, Li S, et al.Paeoniflorin attenuates cuproptosis and ameliorates left ventricular remodeling after AMI in hypobaric hypoxia environments[J]. J Nat Med, 2024, 78(3):664-676.
[18] Kurklu HA, Tan TS.Systemic immune- inflammation index predicts post-MI left ventricular remodeling[J]. Int J Cardiovasc Imaging, 2024, 40(5):991-1000.
[19] Xie F, Yu Z, Xiong Y, et al.Systemic immune-inflammation index and in-stent restenosis in patients with acute coronary syndrome: a single-center retrospective study[J]. Eur J Med Res, 2024, 29(1):145.
[20] Sulo G, Igland J, Vollset SE, et al.Heart Failure Complicating Acute Myocardial Infarction; Burden and Timing of Occurrence: A Nation-wide Analysis Including 86 771 Patients From the Cardiovascular Disease in Norway (CVDNOR) Project[J]. J Am Heart Assoc, 2016, 5(1):e002667.
[21] He Z, Gao B, Deng Y, et al.Associations between systemic immune-inflammation index and heart failure: A cross-sectional study[J]. Medicine (Baltimore), 2024, 103(42):e40096.
[22] 张忠满,朱轶,陈旭锋,等.全身免疫炎症指数对非ST段抬高型心肌梗死患者早期发生急性心力衰竭的预测价值[J].南京医科大学学报(自然科学版),2025,45(3):382-388.
[23] Yang YL, Wu CH, Hsu PF, et al.Systemic immune-inflammation index (SII) predicted clinical outcome in patients with coronary artery disease[J]. Eur J Clin Invest, 2020, 50(5):e13230.
[24] Saylik F, Akbulut T.Systemic Immune-Inflammation Index Predicts Major Cardiovascular Adverse Events in Patients with ST-Segment Elevated Myocardial Infarction[J]. Arq Bras Cardiol, 2022, 119(1):14-22.
[25] Zhou Y, Chen S, Huang L, et al.Definite stent thrombosis after drug-eluting stent implantation in coronary bifurcation lesions: A meta-analysis of 3,107 patients from 14 randomized trials[J]. Catheter Cardiovasc Interv, 2018, 92(4):680-691.
[26] Kristensen SL, Galløe AM, Thuesen L, et al.Stent thrombosis is the primary cause of ST-segment elevation myocardial infarction following coronary stent implantation: a five year follow-up of the SORT OUT II study[J]. PLoS One, 2014, 9(11):e113399.
[27] Wolak A, Amit G, Cafri C, et al.Increased long term rates of stent thrombosis and mortality in patients given clopidogrel as compared to ticlopidine following coronary stent implantation[J]. Int J Cardiol, 2005, 103(3):293-7.
[28] Zheng PG, Chen P, Wang LJ, et al.The association of the systemic immune-inflammation index and stent thrombosis in myocardial infarction patients after coronary stent implantation-a retrospectively study[J]. J Thorac Dis, 2023, 15(4):1726-1733.
[29] Akboga MK, Inanc IH, Sabanoglu C, et al.Systemic Immune-Inflammation Index and C-Reactive Protein/Albumin Ratio Could Predict Acute Stent Thrombosis and High SYNTAX Score in Acute Coronary Syndrome[J]. Angiology, 2023, 74(7):693-701.
[30] Öcal L, Keskin M, Cerşit S, et al.Systemic immune-inflammation index predicts in-hospital and long-term outcomes in patients with ST-segment elevation myocardial infarction[J]. Coron Artery Dis, 2022, 33(4):251-260.
[31] Annibali G, Scrocca I, Aranzulla TC, et al."No-Reflow" Phenomenon: A Contemporary Review[J]. J Clin Med, 2022, 11(8):2233.
[32] Pantea-Rosan LR, Pantea VA, Bungau S, et al.No-Reflow after PPCI-A Predictor of Short-Term Outcomes in STEMI Patients[J]. J Clin Med, 2020, 9(9):2956.
[33] 马晨,张祎,张晶,等.ST段抬高型心肌梗死患者全身免疫炎症指数对无复流发生的影响[J].心肺血管病杂志,2023,42(12):1219-1225.
[34] 张莉侠,董锦丽.全身免疫炎症指数对急性ST段抬高型心肌梗死患者PCI术后无复流的预测价值[J].医学临床研究,2024,41(3):352-355.
[35] Pedersen F, Butrymovich V, Kelbæk H, et al.Short- and long-term cause of death in patients treated with primary PCI for STEMI[J]. J Am Coll Cardiol, 2014, 64(20):2101-8.
[36] Kristensen SD, Laut KG, Fajadet J, et al.Reperfusion therapy for ST elevation acute myocardial infarction 2010/2011: current status in 37 ESC countries[J]. Eur Heart J, 2014, 35(29):1957-70.
[37] Marchi F, Pylypiv N, Parlanti A, et al.Systemic Immune-Inflammation Index and Systemic Inflammatory Response Index as Predictors of Mortality in ST-Elevation Myocardial Infarction[J]. J Clin Med, 2024, 13(5):1256.
[38] Yaşan M, Özel R, Yildiz A, et al.The predictive value of systemic immune-inflammation index for long-term cardiovascular mortality in non-ST segment elevation myocardial infarction[J]. Coron Artery Dis, 2024, 35(3):179-185.
[39] Chen Y, Xie K, Han Y, et al.An Easy-to-Use Nomogram Based on SII and SIRI to Predict in-Hospital Mortality Risk in Elderly Patients with Acute Myocardial Infarction[J]. J Inflamm Res, 2023, 16:4061-4071.
[40] Bian X, He J, Zhang R, et al.The Combined Effect of Systemic Immune-Inflammation Index and Type 2 Diabetes Mellitus on the Prognosis of Patients Undergoing Percutaneous Coronary Intervention: A Large-Scale Cohort Study[J]. J Inflamm Res, 2023, 16:6415-6429.