残余胆固醇水平与老年心房颤动发病风险的相关性研究

摘要/Abstract

摘要： 目的探讨残余胆固醇（RC）水平与老年心房颤动（AF）发病风险的相关性,为老年AF发生风险提供早期诊断依据。方法选取2022年5月至2024年11月于本院初诊的老年心房颤动住院患者共67例,为病例组。从同期进行老年健康体检者中随机选取共67例,为对照组。记录两组人群的临床数据：性别、年龄、吸烟史、有无合并高血压病、糖尿病、冠心病、使用降血脂药物等情况以及甘油三酯（TG）、总胆固醇（TC）、高密度脂蛋白胆固醇（HDL-C）、低密度脂蛋白胆固醇（LDL-C）、RC水平,应用多因素Logistic回归性分析老年AF发病关联的危险因素,感受性曲线（ROC）分析残余胆固醇与老年AF发病之间的关联。结果病例组的RC与TC、HDL-C、LDL-C水平均明显低于对照组,差异有统计学意义（P<0.05）; Logistic回归性分析老年AF发病的相关因素,结果显示RC与TC、HDL-C、LDL-C水平均是老年AF的独立危险因素;ROC曲线显示,相较于其他血脂指标,残余胆固醇也有较高的曲线下面积为0.638（95%CI,0.544-0.732）,提示其与老年AF发病有较高的相关性。结论血清RC水平降低的老年AF发病风险较高,且RC降低与老年AF发病呈负相关,为早期预测老年AF发病具有重要意义。

关键词: 老年, 心房颤动, 血脂代谢, 残余胆固醇, 发病风险, 相关性

康栋梁, 刘文捷, 吴玉婷, 李庆双. 残余胆固醇水平与老年心房颤动发病风险的相关性研究[J]. 心血管病防治知识, 2025, 15(9): 6-9.

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