关键词: 妊娠期高血压, 杞菊地黄汤, 硝苯地平控释片, 血压水平, 妊娠结局

Abstract: Objective To investigate the clinical effect of modified Qiju Dihuang decoction combined with nifedipine controlled-release tablets in the treatment of patients with pregnancy-induced hypertension (PIH) and liver-kidney Yin deficiency syndrome. Methods A total of 88 PIH patients who were admitted to our hospital were divided into control group and observation group using a random number table, with 44 patients in each group. The patients in the control group were given nifedipine controlled-release tablets, and those in the observation group were given modified Qiju Dihuang decoction in addition to the treatment in the control group, with a treatment cycle of 1 month for both groups. The two groups were compared in terms of related data and adverse events after treatment. Results The observation group had a better treatment outcome than the control group, and compared with the control group, the observation group had a significantly lower blood pressure (P<0.05), significantly longer prothrombin time (12.56±0.71 s vs 11.48±0.63 s, P<0.05) and activated partial thromboplastin time (27.68±1.39 s vs 25.41±1.33 s, P<0.05), and a significantly lower level of fibrinogen (3.08±0.28 g/L vs 3.65±0.32 g/L, P<0.05). After treatment, the observation group had significantly lower traditional Chinese medicine syndrome scores than the control group (0.82±0.14, 0.78±0.12, 0.74±0.11, and 0.62±0.12 points vs 1.01±0.18, 0.96±0.15, 0.89±0.13, and 0.75±0.15 points, P<0.05), as well as a significantly lower number of patients with adverse pregnancy outcomes (P<0.05). There was no significant difference in adverse events between the two groups (P>0.05). Conclusion Modified Qiju Dihuang decoction combined with nifedipine controlled-release tablets can better control the blood pressure of PIH patients, avoid coagulation abnormalities, and reduce the risk of adverse pregnancy outcomes, with good safety and feasibility.

Key words: Pregnancy-induced hypertension, Qiju Dihuang decoction, Nifedipine controlled-release tablets, Blood pressure, Pregnancy outcome