不同时间段服用降压药物治疗单纯夜间高血压的疗效评价

摘要/Abstract

摘要： 目的研究睡前服用降压药物与晨起服用降压药物对单纯夜间高血压(isolated nocturnal hypertension,INH)患者的临床治疗效果。方法入选2022年1月至2023年3月在马鞍山临床学院诊断为单纯夜间高血压患者220例。采用随机数字表法分为研究组（n=110,睡前给药）和对照组（n=110,晨起给药）,比较两组患者基线资料、治疗1月后血压情况、血压达标率、非杓型血压检出率、靶器官损害情况和不良反应发生率。结果（1）研究组及对照组患者的白天和夜间平均收缩压（SBP）、舒张压（DBP）水平均显著低于治疗前,差异有统计学意义（P<0.05）;并且治疗后,研究组患者的夜间平均SBP和DBP均较对照组低（P<0.05）;两组患者治疗后的白天SBP和DBP无统计学差异（P>0.05）。（2）服药1月后研究组血压达标率高于对照组（P<0.05）;研究组非杓型血压检出率较治疗前降低（P<0.05）,且研究组非杓型血压检出率低于对照组（P<0.05）。（3）治疗后研究组颈部斑块检出率低于对照组（P<0.05）,两组患者治疗后的估计肾小球滤过率（eGFR）无统计学差异（P>0.05）。治疗后两组患者的心脏、肾脏、脑靶器官损害率及心脑血管事件发生率均较对照组相比无统计学差异（P>0.05）。（4）两组患者的不良反应发生率无统计学意义（P>0.05）。结论单纯夜间高血压患者,睡前服用降压药物可有效降低夜间血压水平以及恢复正常的血压昼夜节律变化,降压效果更明显、提高血压达标率,减少颈动脉斑块发生,且不增加不良反应。

鲁朝霞, 杨达, 王岳松. 不同时间段服用降压药物治疗单纯夜间高血压的疗效评价[J]. 心血管病防治知识, 2024, 14(8): 6-10.

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