染色质重塑在心血管疾病中的研究进展

摘要/Abstract

摘要： 心血管疾病是全球范围内致残率和致死率最高的疾病类型,严重威胁公共卫生安全。作为表观遗传调控的核心机制之一,染色质重塑通过动态改变染色质空间结构和可及性,精确调控基因的时空特异性表达。染色质重塑异常与动脉粥样硬化、心肌肥厚、心力衰竭等多种心血管疾病的发生发展密切相关,本文系统综述了染色质重塑在动脉粥样硬化等心血管疾病中的分子机制,重点探讨了染色质重塑因子BRG1/BRM、CHD家族等在疾病进程中的调控作用,为靶向染色质重塑的心血管治疗策略和开发新药物提供理论依据。

关键词: 染色质重塑, 心血管疾病, DNA甲基化, 组蛋白修饰

马苏怡, 朱瑞功. 染色质重塑在心血管疾病中的研究进展[J]. 心血管病防治知识, 2026, 16(3): 138-144.

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