Meta分析长期血液透析与心房颤动的相关性研究

摘要/Abstract

摘要： 目的系统评价长期血液透析与心房颤动的相关性,以为临床提供循证依据。方法检索知网、万方、PubMed等数据库,收集长期血液透析与心房颤动相关性的观察性研究,提取相关文件并进行质量评估后,采用Rev Man 5.1统计学软件包进行Meta分析。结果共纳入13篇文献,包括8485例患者。各研究内两组间的一般资料均无明显差异。Meta分析结果显示,血液透析患者中心房颤动的发生率为12.0%（95%CI: 10.5%-13.5%）。血液透析患者中心房颤动的风险显著增加（OR=0.66,95%CI: 0.59-0.86,P<0.001）。透析时间较长的患者心房颤动的发生率显著增加（OR=1.86,95%CI: 1.18-3.15,P<0.001）。Egger's试验和Begg's漏斗图用于评估发表偏倚,Egger's线性回归试验（P=0.807）和Begg's秩相关检验（Pr>|Z|= 0.707 ）,漏斗图未显示出偏移。结论长期血液透析可增加心房颤动的发病率,两者之间存在相关性。

关键词: 长期血液透析, 心房颤动, 相关性, Meta

Abstract: Objective To investigate the association between long-term hemodialysis and atrial fibrillation, and to provide evidence-based data for clinical practice. Methods Databases including CNKI, Wanfang Data, and PubMed were searched for observational studies on the association between long-term hemodialysis and atrial fibrillation. After related articles were extracted and quality assessment was performed, RevMan 5.1 software was used to perform the meta-analysis. Results A total of 13 articles were included, involving 8485 patients. There were no significant differences in general data between the two groups in each study. The meta-analysis showed that the incidence rate of atrial fibrillation was 12.0% (95% confidence interval [CI]: 10.5%-13.5%) in patients undergoing hemodialysis. There was a significant increase in the risk of atrial fibrillation in patients undergoing hemodialysis (odds ratio [OR]=0.66, 95%CI:0.59-0.86, P<0.001), and there was a significant increase in the incidence rate of atrial fibrillation in patients undergoing hemodialysis for a relatively long time (OR=1.86, 95%CI:1.18-3.15, P<0.001). The Egger’s linear regression test and the Begg’s funnel plots were used to assess publication bias, with P=0.807 and Pr>|Z|=0.707, respectively, and the funnel plots did not show the presence of publication bias. Conclusion Long-term hemodialysis can increase the incidence rate of atrial fibrillation, and there is an association between long-term hemodialysis and atrial fibrillation.

Key words: Long-term hemodialysis, Atrial fibrillation, Association, Meta-analysis

李梅, 梁建权, 梁少霞. Meta分析长期血液透析与心房颤动的相关性研究[J]. 心血管病防治知识, 2025, 15(13): 3-8.

LI Mei, LIANG Jianquan, LIANG Shaoxia. Association between long-term hemodialysis and atrial fibrillation: A meta-analysis[J]. Prevention and Treatment of Cardiovascular Disease, 2025, 15(13): 3-8.

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