胃泌素17和血清胃蛋白酶原I与冠心病的关系

摘要/Abstract

摘要： 目的探讨血清胃功能（胃泌素17、胃蛋白酶原I和Ⅱ及两者比值）与冠心病的关系。方法选择2019年1月至2020年5月徐州医科大学附属医院住院患者,其中冠心病262例和慢性胃炎67例,对照组健康体检者176例,对三组进行空腹采集静脉血,采用酶联免疫法定量检测胃功能四项的浓度,比较三组胃功能四项浓度的差异。结果冠心病组和慢性胃炎组血清PGI和G-17水平明显高于对照组（P<0.01）,差异有统计学意义;慢性胃炎组血清PGII水平高于对照组（P<0.05）,差异有统计学意义;而两组血清PGI和PGII比值（PGR）与对照组相比,差异无统计学意义（P>0.05）。结论冠心病和慢性胃炎患者的血清PGI和G-17与正常健康者相比,浓度明显升高,提示临床医生在排除胃部疾病的情况下,其浓度的升高可能对筛查冠心病意义重大,具有一定的临床应用价值。

关键词: 冠心病, 胃功能, 胃泌素17, 血清胃蛋白酶原I

程守全, 梁妍, 徐敏. 胃泌素17和血清胃蛋白酶原I与冠心病的关系[J]. 心血管病防治知识, 2022, 12(7): 24-26.

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