Objective To statistically analyze the ambulatory blood pressure monitoring results of 280 patients, to investigate the clinical application value of ambulatory blood pressure, to provide a reliable basis for clinicians in the treatment of hypertension, to guide the clinical medication of hypertensive patients, and to improve the rate of reaching the standard for 24-hour blood pressure control. Methods A noninvasive portable ambulatory blood pressure monitor was used to perform ambulatory blood pressure monitoring for 280 patients with hypertension who attended our hospital due to symptoms or were found to have hypertension by medical examination for enrollment from September 2020 to August 2024, and the monitoring results were analyzed. Results Among the 280 patients, there were 221 patients with hypertension, 12 with hypotension, and 47 with normal blood pressure, and there were 200 patients with normal circadian rhythm (including 22 patients with morning hypertension) and 80 with abnormal circadian rhythm, among whom 60 had non-dipper blood pressure pattern, 11 had reverse-dipper blood pressure pattern, and 9 had extreme-dipper blood pressure pattern. Compared with the non-hypertension group, the hypertension group had a significantly higher proportion of patients with abnormal circadian rhythm (35.29% vs 3.51%, P<0.05). Conclusion Ambulatory blood pressure monitoring can identify morning hypertension and nocturnal hypertension that cannot be detected by office blood pressure, and it can also exclude white coat hypertension and detect postprandial hypotension and orthostatic hypotension. It can provide reliable data for reaching the standard for blood pressure control throughout the day, and it has important significance for the diagnosis, exclusion, and individualized treatment of hypertension.