Objective To investigate the current status of self-nursing intervention in patients with hypertension and the effect of qualitative self-management guiding regimen on self-management behavior and blood pressure. Methods A total of 46 patients with hypertension who were treated in our hospital from January 2019 to January 2023 were enrolled as subjects, and they were divided into experimental group and control group using a random number table, with 30 patients in each group. The patients in the control group received routine nursing management, while those in the experimental group received intervention with the qualitative self-management guiding regimen in addition to the management in the control group. The patients were analyzed in terms of self-management behavior, blood pressure, activities of daily living, and prognosis. Results After intervention, compared with the control group, the experimental group had a significantly higher self-management behavior score (P<0.05), significantly lower systolic pressure and diastolic pressure (P<0.05), and a significantly higher Barthel Index (P<0.05). Conclusion For patients with hypertension, the qualitative self-management guiding regimen can enhance their self-management behavior, control blood pressure stability, and promote the improvement in activities of daily living, and therefore, it holds promise for clinical application.