Objective To investigate the clinical value of serum BNP and LCN-2 in evaluating the disease severity and prognosis of patients with chronic heart failure. Methods A total of 90 patients with heart failure who were treated in our hospital from January 2019 to June 2023 were enrolled as observation group, and 90 individuals who underwent cardiac examination in our hospital during the same period of time and had normal results were enrolled as control group. The two groups were compared in terms of the serum levels of BNP and LCN-2, and their clinical value in evaluating the disease severity and prognosis of patients with chronic heart failure was analyzed. Results Compared with the control group, the observation group had significantly higher levels of LCN-2 (89.678±17.48 ng/mL vs 60.04±15.31 ng/mL, t=9.782, P<0.05) and BNP (2568.11±478.28 pg/mL vs 196.41±47.49 pg/mL, t=24.543, P<0.05). In the observation group, the levels of BNP and LCN-2 increased with the increase in cardiac functional grade (F=19.261 and 602.689, P<0.05). In the observation group, there were 14 patients with major adverse cardiovascular events and 76 without such events, and the patients with major adverse cardiovascular events had significantly higher levels of BNP and LCN-2 than those without such events (t=2.218 and 2.221, P<0.05). Conclusion Changes in the levels of BNP and LCN-2 have a reliable clinical value in evaluating the disease severity and prognosis of patients with chronic heart failure and thus holds promise for clinical application.

Objective To investigate the clinical features of different types of aortic dissection, and to improve the ability for the diagnosis and treatment of aortic dissection. Methods The data of 68 patients with aortic dissection were analyzed, including baseline data, risk factors, clinical symptoms, treatment, and prognosis. Results Among the 68 patients with aortic dissection, 42 (61.76%) had Stanford A type aortic dissection and 26 (38.24%) had Stanford B type aortic dissection. Related risk factors were hypertension in 59 patients (86.76%), smoking in 26 patients (38.24%), and hyperlipidemia in 23 patients (33.82%), and there were no significant differences in risk factors between Stanford A type aortic dissection and Stanford B type aortic dissection. Of all patients, 61 (89.71%) had an initial symptom of chest/back/abdominal pain, and 7 (10.29%) had no obvious pain, and the patients with aortic dissection could also have the symptoms of lesions in the organs involved, such as acute myocardial infarction and intestinal obstruction. The initial symptom was chest pain for Stanford A type aortic dissection and abdominal pain for Stanford B type aortic dissection, with a significant difference between the two types. Conclusion Aortic dissection tends to have a high mortality rate and diverse clinical manifestations, and therefore, clinicians for initial diagnosis need to make an early diagnosis and perform early treatment, so as to improve the prognosis of patients.

The Sirtuin family is a group of important functional proteins in the human body, and the role of Sirt2 protein remains unclear; however, in recent years, studies have been conducted to investigate the structure and function of Sirt2 protein and have basically clarified its important mechanism of action at the cellular level and the metabolic level. The abnormal expression of Sirt2 may induce or aggravate cardiovascular diseases. This article analyzes the mechanism of action of Sirt2 and its role in pathology and summarizes the latest research advances for further clinical application, so as to provide new ideas for the diagnosis and treatment of related cardiovascular diseases.