Objective To analyze the frequency distribution of seven antihypertensive drug-related genes in the population in Tongliao, China, and to provide a theoretical basis for the precise medication for local hypertensive patients. Methods A total of 401 hypertensive patients admitted to the AffiliatedHospitalofInner MongoliaUniversity for Nationalities in Tongliao from September 2021 to June 2022 were enrolled as study subjects. The ligase-mediated fluorescent probe technique was used to determine the single nucleotide polymorphisms of seven genes associated with five antihypertensive drugs (β-receptor blockers, angiotensin II receptor antagonists, angiotensin-converting enzyme inhibitors, diuretics, and calcium antagonists). The gene frequency differences were analyzed among patients of different sexes, nationalities, and regions. Results The mutant allele frequencies of CYP2D6*10, ADRB1(1165G>C), CYP2C9*3, AGTR1(1166A>C), ACE(I/D), NPPA(T2238C), and CYP3A5*3 of the 401 patients were 41.77%, 73.82%, 3.99%, 4.99%, 34.54%, 1.25%, and 72.94%, respectively. Significant differences were found in the NPPA gene frequency distribution between different sexes(P<0.05), in the CYP2D6*10 and CYP3A5*3 gene frequency distribution between different ethnic groups(P<0.05), and in the CYP2D6*10 gene frequency distribution between different regions (P<0.05). Conclusion The genes CYP2D6*10, ADRB1 (1165G>C), and CYP3A5*3 have a high mutation frequency in the hypertensive patients in Tongliao, indicating a good effect of β-receptor blockers and calcium antagonists in the population in this region. This providesa reference value for clinicians in choosing the right antihypertensive drugs.

Objective To explore the application of phased health education combined with 5E rehabilitation nursing in patients with coronary heart disease (CHD) who have undergone percutaneous coronary intervention (PCI) in the emergency intensive care room (EICU) and its impact on their quality of life. Methods Seventy-eight patients with CHD who underwent PCI in the EICU in our hospital from June 2020 to March 2021 were enrolled in the study. The patients were divided into two groups (with 39 cases in each group) using a random number table. The control group received conventional intervention after PCI, while the observation group received phased health education combined with 5E rehabilitation nursing in addition to the conventional intervention. The two groups were compared for the intervention effects. Results After the intervention, the scores of heart function and exercise tolerance were significantly higher in the observation group than in the control group (P<0.05). Furthermore, the scores of the quality of life and self-management were significantly higher in the observation group than in the control group (P<0.05). Conclusion Phased health education combined with 5E rehabilitation nursing in patients with CHD who have undergone PCI in the EICU can significantly improve patients' heart function, self-management behaviors, and quality of life.