Objective To investigate the risk factors for contrast-induced nephropathy in patients with acute coronary syndrome undergoing coronary interventional therapy. Methods A retrospective analysis was performed for the patients with acute coronary syndrome who underwent coronary interventional therapy in Xingtai People's Hospital from March 2017 to December 2019, among whom there were 65 patients with contrast-induced nephropathy and 417 patients without contrast-induced nephropathy. Results The incidence rate of contrast-induced nephropathy was 13.49% among the patients with acute coronary syndrome undergoing coronary interventional therapy. The multivariate logistic regression analysis showed that renal insufficiency (odds ratio [OR] = 32.850, 95% confidence interval [CI]: 2.730-395.229, P<0.05) and cardiac insufficiency (OR = 7.102, 95% CI: 3.060-16.482, P<0.05) were risk factors for contrast-induced nephropathy in patients with acute coronary syndrome undergoing coronary interventional therapy, while age ≤75 years (OR = 0.209, 95% CI: 0.061-0.709, P<0.05), hydration (OR = 0.085, 95% CI: 0.033-0.218, P<0.05), and serum creatinine <0.5 mg/dL (OR = 0.025, 95% CI: 0.003-0.252, P<0.05) were protective factors against contrast-induced nephropathy. Conclusion There is a high incidence rate of contrast-induced nephropathy in patients with acute coronary syndrome undergoing coronary interventional therapy, and cardiac insufficiency, renal insufficiency, old age, serum creatinine ≥0.5 mg/dL, and absence of hydration are risk factors for contrast-induced nephropathy in such patients.