Objective To investigate the value of preoperative soluble ST2 (sST2) level in predicting ventricular wall motion abnormality after emergency percutaneous coronary intervention (PCI). Methods A prospective analysis was performed for the clinical and laboratory data of 114 patients with acute myocardial infarction who underwent emergency PCI in Taizhou People's Hospital from January to September, 2019. Echocardiography was performed at 1 week after surgery, and wall motion score (WMS) was calculated to evaluate wall motion. According to preoperative sST2 level, the patients were divided into Q1 group (10.71-39 ng/mL, 38 patients), Q2 group (39.11-68 ng/mL, 38 patients), and Q3 group (69-254.21 ng/mL, 38 patients), and the three groups were compared in terms of clinical data, laboratory data, left ventricular ejection fraction, and WMS. A multivariate linear regression analysis was used to investigate the influencing factors for WMS after emergency PCI. Results There was a significant difference in WMS between groups, and the Q3 group had a significantly higher WMS than the Q1 group [21 (20.75-23) vs 17 (17-18), P<0.001]. The multivariate analysis showed that high preoperative sST2 level was an independent risk factor for WMS after emergency PCI (β= 0.321, P<0.001). Other independent risk factors included high troponin I level, lesions in the anterior descending branch, high thrombus load, and a medical history of hypertension. Conclusion High preoperative sST2 level is an independent risk factor for ventricular wall motion abnormality after emergency PCI and has a certain value in the early prediction of the extent of ischemic infarction.