Abstract: Objective To investigate the value of heart-type fatty acid-binding protein (H-FABP) andpro-B-type natriuretic peptide (proBNP) in the diagnosis and evaluation of rapid atrial fibrillation. Methods A total of 79 patients with rapid atrial fibrillation who were admitted to Department of Emergency, The People's Hospital of Fangzi District, from January 2021 to December 2022 were enrolled, and double-antibody sandwich enzyme-linked immunosorbent assay was used to measure the plasma levels of H-FABP and proBNP. A comprehensive analysis was performed based on clinical manifestation and cardiac function testing. Results The mean level of plasma H-FABP was (7.0±1.7)ng/mL in patients with paroxysmal atrial fibrillation,(8.3±2.2)ng/mL in patients with persistent atrial fibrillation, and 9.5±3.0 ng/mL in patients with permanent atrial fibrillation, while the mean level of proBNP in these three groups of patients was (819±125)pg/mL,(1630±215)pg/mL, and (2189±165)pg/mL, respectively. For the patients with paroxysmal atrial fibrillation, the levels of H-FABPand proBNP were reduced significantly to (6.2±1.1)ng/mL and (561±117)pg/mL, respectively, after cardioversion with amiodarone. Based on NYHA classification for cardiac function, the patients with grade III/IV cardiac function had significantly higher levels of H-FABPand proBNP than those with good cardiac function. Conclusion The plasma levels of H-FABPand proBNP are significantly associated with the cardiac function of patients with rapid atrial fibrillation, and therefore, they can be used as potential biomarkers for the diagnosis of atrial fibrillation and the evaluation of cardiac function.

Key words: Coronary artery, Elderly patients, Interventional therapy, Percutaneous radial artery puncture, Femoral artery puncture