Objective To investigate the value of soluble suppression of tumorigenesis 2 (sST2) in predicting the formation of coronary collateral circulation in patients with acute myocardial infarction after percutaneous coronary intervention. Methods A total of 85 patients with ST-elevation myocardial infarction (STEMI) who were admitted to The First People's Hospital of Jining from June 2020 to July 2023 and underwent emergency percutaneous coronary intervention (PCI) were enrolled as subjects. After admission, all patients underwent emergency PCI according to the latest guidelines for the treatment of acute STEMI, and standard angiography was performed to collect coronary collateral circulation data. Collateral circulation was graded according to the Rentrop's grading system: collateral circulation without filling any blood vessels as grade 0; small collateral filling as grade 1; partial epicardial artery filling as grade 2; complete epicardial artery perfusion as grade 3. Grades 0 and 1 were considered as poor collateral circulation formation, and grades 2 and 3 were considered as good collateral circulation formation. The patients were divided into good collateral circulation group with 33 patients and poor collateral circulation group with 52 patients. ELISA was used to measure the serum level of sST2 before intervention on day 1 of admission, and all patients underwent emergency PCI. General data were compared between the good collateral circulation group and the poor collateral circulation group. A logistic regression analysis was used to investigate risk factors, and the area under the ROC curve (AUC) was used to analyze the serum level of sST2 on admission and its value in predicting collateral circulation in patients with STEMI. Results The retrospective analysis showed that among the 85 patients, 33 had good coronary collateral circulation and 52 had poor coronary collateral circulation, resulting in a rate of coronary collateral circulation of 38%. The poor collateral circulation group had a significantly higher serum level of sST2 than the good collateral circulation group (P<0.05). The serum level of sST2 on admission had an AUC of 0.706 (95% confidence interval: 0.579-0.833, P<0.05) in predicting collateral circulation after PCI in patients with STEMI. Conclusion The level of sST2 has a good value in predicting the formation of coronary collateral circulation in STEMI patients.

Objective To investigate the application effect of percutaneous radial artery puncture versus femoral artery puncture in coronary intervention for elderly patients with coronary artery disease. Methods A total of 210 elderly patients with coronary artery disease who were admitted to Changle District People's Hospital from June 2021 to November 2023 were enrolled, and according to the procedure for puncture in interventional treatment, they were divided into radial artery group and femoral artery group, with 105 patients in each group. The patients in the radial artery group received radial artery puncture, and those in the femoral artery group received femoral artery puncture. The two groups were compared in terms of puncture indicators, surgical conditions, recovery, and complications. Results As for the puncture indicators, compared with the femoral artery group, the radial artery group had a significantly lower average number of punctures, a significantly longer time to successful puncture, a significantly shorter time of sheath implantation, and a significantly shorter bleeding time (all P<0.05). As for the surgical conditions, compared with the femoral artery group, the radial artery group had a significantly higher first-attempt success rate of puncture and significantly higher success rates of imaging and surgery (all P<0.05). As for the condition of recovery, compared with the femoral artery group, the radial artery group had a significantly lower Visual Analogue Scale score on days 1 and 3 after surgery and a significantly shorter length of hospital stay (all P<0.05). The radial artery group had a significantly lower incidence rate of postoperative complications than the femoral artery group (3.81% vs 11.43%, P<0.05). Conclusion Both percutaneous radial artery puncture and femoral artery puncture can be used in coronary intervention for elderly patients with coronary artery disease. In comparison, percutaneous radial artery puncture has more advantages in elderly patients with coronary artery disease, such as a high first-attempt success rate of puncture, a short time of sheath implantation and bleeding, fast postoperative recovery, and a low risk of complications.

Objective To investigate the value of heart-type fatty acid-binding protein (H-FABP) andpro-B-type natriuretic peptide (proBNP) in the diagnosis and evaluation of rapid atrial fibrillation. Methods A total of 79 patients with rapid atrial fibrillation who were admitted to Department of Emergency, The People's Hospital of Fangzi District, from January 2021 to December 2022 were enrolled, and double-antibody sandwich enzyme-linked immunosorbent assay was used to measure the plasma levels of H-FABP and proBNP. A comprehensive analysis was performed based on clinical manifestation and cardiac function testing. Results The mean level of plasma H-FABP was (7.0±1.7)ng/mL in patients with paroxysmal atrial fibrillation,(8.3±2.2)ng/mL in patients with persistent atrial fibrillation, and 9.5±3.0 ng/mL in patients with permanent atrial fibrillation, while the mean level of proBNP in these three groups of patients was (819±125)pg/mL,(1630±215)pg/mL, and (2189±165)pg/mL, respectively. For the patients with paroxysmal atrial fibrillation, the levels of H-FABPand proBNP were reduced significantly to (6.2±1.1)ng/mL and (561±117)pg/mL, respectively, after cardioversion with amiodarone. Based on NYHA classification for cardiac function, the patients with grade III/IV cardiac function had significantly higher levels of H-FABPand proBNP than those with good cardiac function. Conclusion The plasma levels of H-FABPand proBNP are significantly associated with the cardiac function of patients with rapid atrial fibrillation, and therefore, they can be used as potential biomarkers for the diagnosis of atrial fibrillation and the evaluation of cardiac function.