同型半胱氨酸以及抑郁情绪与冠心病的相关性分析

摘要/Abstract

摘要： 目的探讨血清同型半胱氨酸、抑郁与冠状动脉病变的相关性分析。方法收集贵州医科大学附属医院心血管内科心血管内科的CHD患者118例（其中SAP45例,ACS 72例）作为冠心病组;同时选取同期本院体检者120例作为对照组;所有冠心病组完善冠状动脉造影术。结果（1）冠心病组的同型半胱氨酸水平及抑郁情绪发生率（22.10±7.46,34.74%）明显高于对照组（12.13±4.14,21.66%）,差异具有统计学意义（P<0.05）。在冠心病组内,SAP亚组的Hcy水平高于ACS亚组,差异具有统计学意义（P<0.05）,SAP亚组与ACS亚组的抑郁情绪发生率比较,差异无统计学意义（P>0.05）。（2）同型半胱氨酸、抑郁情绪为冠心病的危险因素（P<0.001）。（3）在冠心病组中,HHcy亚组的Gensini分值[41（20,56）]明显高于正常Hcy组[21.5（13,32）],差异有统计学意义（P<0.05）;抑郁亚组和非抑郁亚组的Gensini分值比较,差异无统计学意义（P>0.05）。（4）冠心病人群中,抑郁情绪与Hcy存在一定的关系,但Hcy水平与抑郁的严重程度无明显相关性（P>0.05）;非心脏疾病人群中（对照组）的抑郁情绪与Hcy水平无明显相关性（P>0.05）。结论（1）同型半胱氨酸是冠心病的一个独立危险因素,同时高同型半胱氨酸血症与冠脉病变的严重程度有关。（2）抑郁是冠心病的危险因素,冠心病患者是否合并抑郁情绪以及抑郁情绪的严重程度可能与冠脉病变程度无关。（3）在冠心病中,抑郁情绪与同型半胱氨酸水平存在一定的相关性。

关键词: 同型半胱氨酸, 冠心病, 抑郁, 冠状动脉狭窄

Abstract: Objective To investigate the association of serum homocysteine and depression withcoronary heart disease (CHD). Methods A total of 118 patients with CHD who were treated in Department of Cardiology, The Affiliated Hospital of Guizhou Medical University, were enrolled as CHD group, with 45 patients withstable angina pectoris(SAP) and 72 with acute coronary syndrome (ACS), and 120 healthy individuals who underwent physical examination in our hospital during the same period of time were enrolled as control group. Coronary angiography was performed for all patients in the CHD group. Results Compared with the control group, the CHD group had significantly higher homocysteine level (22.10±7.46 vs 12.13±4.14, P<0.05) and incidence rate of depression (34.74% vs 21.66%, P<0.05). The CHD group was further divided into SAP subgroup and ACS subgroup, and the SAP subgroup had a significantly higher homocysteinelevel than the ACS subgroup (P<0.05), while there was no significant difference in the incidence rate of depression between the two subgroups (P>0.05). Homocysteine and depression were risk factors for CHD (P<0.001). In the CHD group, the high-homocysteine subgroup had a significantly higher Gensini score than the normal homocysteine subgroup [41(20,56) vs 21.5(13,32), P<0.05], while there was no significant difference in Gensini score between the depression subgroup and the non-depression subgroup (P>0.05). Depression was associated with homocysteine in the patients with CHD, but homocysteine level was not correlated with the severity of depression (P>0.05); in the population without heart disease (the control group), depression was not associated with homocysteine level (P>0.05). Conclusion Homocysteine is an independent risk factor for CHD, and hyperhomocysteinemia is associated with the severity of coronary artery disease. Depression is a risk factor for CHD, and the presence or absence of depression and the severity of depression may not be associated with the severity of coronary artery disease. Depression is associated with homocysteine level in patients with CHD.

Key words: Homocysteine; Coronary heart disease; Depression; Coronary artery stenosis

吴晟, 刘兴德. 同型半胱氨酸以及抑郁情绪与冠心病的相关性分析[J]. 心血管病防治知识, 2019, 9(13): 28-33.

WU Sheng, LIU Xing-de. Association ofhomocysteine and depression with coronary heart disease[J]. Prevention and Treatment of Cardiovascular Disease, 2019, 9(13): 28-33.

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