长链非编码RNA在急性心肌梗死病程中的作用机制及研究进展

摘要/Abstract

摘要： 急性心肌梗死（AMI）是心血管疾病致死的主要原因,其病理进程涉及复杂的分子机制。长链非编码RNA（lncRNA）通过时空特异性表达模式,在AMI不同时期动态调控炎症反应、细胞凋亡、心肌纤维化等关键病理机制。现有研究表明lncRNA表达水平的变化与AMI的诊断和预后评估密切相关,但目前临床转化有限。随着技术的发展,lncRNA靶向干预策略在改善心肌损伤中展现出潜力。本文系统阐述lncRNA在AMI病程中的作用机制,整合多组学研究进展及临床转化探索,旨在为开发精准诊疗提供理论依据。

塔伊尔江·图尼亚孜, 何鹏义. 长链非编码RNA在急性心肌梗死病程中的作用机制及研究进展[J]. 心血管病防治知识, 2025, 15(18): 140-144.

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