Objective To investigate the effect of standard sequential grading combined with cognitive remodeling intervention on rehabilitation after percutaneous coronary intervention (PCI) in patients with acute myocardial infarction. Methods A total of 112 patients with acute myocardial infarction who were admitted to Department of Cardiology, Guiqian International General Hospital, were enrolled and divided into control group and observation group using a random number table, with 56 patients in each group. The patients in the control group received perioperative routine nursing combined with cognitive remodeling intervention, and those in the observation group were given standard sequential grading nursing in addition to the intervention in the control group. The outcome after nursing was compared between the two groups, and the indicators for investigation included adverse events, exercise tolerance, andperception of the disease. Results After nursing, compared with the control group, the observation group had significantly better results of six-minute walk test, a significantly higher modified Barthel Index, and a significant increase in the perception of the disease (P<0.05). There was no significant difference in the proportion of patients with adverse events between the two groups at 6 months after discharge (P>0.05). Conclusion Standard sequential grading combined with cognitive remodeling intervention can help to promote rehabilitationafter PCI and improve the understanding of the disease in patients with acute myocardial infarction, and therefore, it holds promise for clinical practice.