Objective To investigate the clinical effect of holistic nursing intervention based on nursing procedure in the perioperative period of patients with uterine myoma and hypertension. Methods A total of 120 patients with uterine myoma and hypertension who were admitted to our hospital from January to December in 2020 were enrolled and divided into observation group and control group using a random number table, with 60 patients in each group. The patients in the control group were given routine nursing, and those in the observation group were given holistic nursing intervention based on nursing procedure. The two groups were compared in terms of related recovery time indices (time to ambulation, time to first defecation, and length of hospital stay) after nursing, improvement in psychological state based on Self-Rating Depression Scale (SDS) and Self-Rating Anxiety Scale (SAS) scores after intervention, and the incidence rate of complications. Results Compared with the control group, the observation group had significantly shorter time to ambulation (23.0±3.2 h vs 28.1±5.6 h, t=7.298, P<0.05), time to first defecation (28.6±5.6 h vs 43.7±12.4 h, t=10.143, P<0.05), and length of hospital stay (6.6±0.8 d vs 9.9±1.1 d, t=22.372, P<0.05). For the patients in the observation group, there were reductions in SDS score (from 63.1±6.1 points before intervention to 27.7±5.2 points after intervention) and SAS score (from 59.2±7.3 points before intervention to 31.6±5.5 points after intervention), and for the patients in the control group, there were also reductions in SDS score (from 64.4±6.6 points before intervention to 38.5±5.3 points after intervention) and SAS score (from 59.0±8.5 points before intervention to 45.4±6.5 points after intervention); however, the observation group had a better improvement than the control group. There were significant differences in SDS and SAS scores between the two groups after intervention (t=13.378 and 14.915, P<0.05). Conclusion For patients with uterine myoma and hypertension, holistic nursing intervention based on nursing procedure helps to alleviate negative emotion, reduce complications, and promote recovery.