Prevention and Treatment of Cardiovascular Disease ›› 2026, Vol. 16 ›› Issue (1): 44-49.

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Relationships of serum systemic immune-inflammation index and triglyceride-glucose index with major adverse cardiovascular events after emergency percutaneous coronary intervention in patients with acute coronary syndrome

WU Jinlong1, LI Xiaomei1, ZHAO Qian1, LIU Fen2,3, SONG Ning1, LIU Zunteng1, YANG Yining3,4,5,6   

  1. 1. The First Affiliated Hospital of Xinjiang Medical University, Urumqi 830054, China;
    2. Clinical Research Institute, The First Affiliated Hospital of Xinjiang Medical University, Urumqi 830011, China;
    3. Key Laboratory of Cardiovascular Disease Research, The First Affiliated Hospital of Xinjiang Medical University, Urumqi 830054, China;
    4. State Key Laboratory of Pathogenesis, Prevention and Treatment of High-Incidence Diseases in Central Asia, Xinjiang Medical University, Urumqi 830054, China;
    5. People's Hospital of Xinjiang Uyghur Autonomous Region, Urumqi 844000, China;
    6. Xinjiang Key Laboratory of Cardiac Vascular Homeostasis and Regenerative Medicine, Urumqi 830011, China
  • Online:2026-01-15 Published:2026-04-14

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Abstract: Objective To analyze the relationships of serum systemic immune-inflammation index (SII) and triglyceride-glucose index (TyG) levels with the occurrence of major adverse cardiovascular events (MACE) in patients with acute coronary syndrome (ACS) undergoing emergency percutaneous coronary intervention (PCI). Methods A total of 918 ACS patients who underwent emergency PCI at The First Affiliated Hospital of Xinjiang Medical University between June 2013 and June 2023 were selected. Clinical information and admission laboratory data were collected. SII was calculated based on routine blood tests, and TyG was calculated based on biochemical tests. Patients were followed up and divided into a MACE group and a non-MACE group based on the occurrence of MACE. Univariable and multivariable logistic regression analyses were performed to identify factors associated with MACE after emergency PCI in ACS patients. Receiver operating characteristic curves were constructed to evaluate the predictive value of serum SII and TyG levels for postoperative MACE in this population． Results The incidence of MACE at 1 year after emergency PCI in the 918 ACS patients was 22.77% (209/918). SII and TyG levels in the non-MACE group were lower than those in the MACE group [SII: 851.23 (576.39, 1305.27) vs 1409.42 (911.48, 1955.90); TyG: 8.82 (8.44, 9.23) vs 9.37 (8.85, 9.83)], with statistically significant differences (P<0.05). Advanced age and elevated SII and TyG levels were identified as independent risk factors for MACE after emergency PCI in ACS patients (P<0.05). The areas under the receiver operating characteristic curves for predicting MACE using serum SII and TyG alone were 0.691 and 0.699, respectively. The area under the curve for the prediction of MACE using both SII and TyG was 0.737, which was higher than that of either index alone. Conclusion Elevated serum SII and TyG levels are associated with an increased risk of MACE after emergency PCI in ACS patients. Combined detection of these two indices demonstrates superior predictive value for postoperative MACE．

Key words: Acute coronary syndrome, Percutaneous coronary intervention, Systemic immune-inflammation index, Triglyceride-glucose index, Major adverse cardiovascular events